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Suspected duplicates in the galactose pathway #400
There are two metabolites in the model called
galactose-1-phosphate[c]
alpha-D-galactose-1-phosphate[c]
According to https://pubchem.ncbi.nlm.nih.gov/compound/alpha-D-Galactose-1-phosphate, these are synonyms
These are then duplicates (interestingly, they have slightly different GPRs, but the same MNX id (I'm not sure how these work exactly though) )
MAR04130 ATP[c] + galactose[c] => ADP[c] + alpha-D-galactose-1-phosphate[c] + H+[c]
MAR04414 ATP[c] + galactose[c] => ADP[c] + galactose-1-phosphate[c] + H+[c]
Also these, although one of them is unidirectional, unclear which it should be. They have the same GPR and same kegg id:
MAR04131 glucose-1-phosphate[c] + UDP-galactose[c] <=> alpha-D-galactose-1-phosphate[c] + UDP-glucose[c]
MAR04132 galactose-1-phosphate[c] + UDP-glucose[c] => glucose-1-phosphate[c] + UDP-galactose[c]
kegg.reaction/R00955
This is the fifth reaction that is concerned (no duplicate found):
MAR08767 alpha-D-galactose-1-phosphate[c] + H+[c] + UTP[c] => PPi[c] + UDP-galactose[c]
Follow-up to #1089, in #1105 (open): The merges are recorded on the kept entities (MAM01322c, MAR04130, MAR04131); GALK1 and GALT get the references UniProt uses; UGP2 on MAR08767 gets human evidence (PMID:12626383) and a note that it is a minor side activity. Details and evidence are in the comment on #1089.
Activity
haowang-bioinfo commentedon May 25, 2023
@johan-gson do you have plan to fix this?
johan-gson commentedon May 25, 2023
Not in the near future, I'm not sure exactly what to do and just got a heavy revision :)
edkerk commentedon Sep 28, 2026
Follow-up to #1089, in #1105 (open): The merges are recorded on the kept entities (MAM01322c, MAR04130, MAR04131); GALK1 and GALT get the references UniProt uses; UGP2 on MAR08767 gets human evidence (PMID:12626383) and a note that it is a minor side activity. Details and evidence are in the comment on #1089.
edkerk commentedon Oct 5, 2026
Fixed in Human 2.1.0.