diff --git a/packages/react-native/package.json b/packages/react-native/package.json
index 6d0af84fc364..bef13959b49d 100644
--- a/packages/react-native/package.json
+++ b/packages/react-native/package.json
@@ -117,8 +117,6 @@
     "scripts/setup-apple-spm.js",
     "scripts/spm",
     "scripts/xcode/asset-catalog.sh",
-    "scripts/xcode/ccache-clang.sh",
-    "scripts/xcode/ccache-clang++.sh",
     "scripts/xcode/ccache.conf",
     "scripts/xcode/with-environment.sh",
     "sdks/.hermesv1version",
diff --git a/packages/react-native/scripts/cocoapods/__tests__/utils-test.rb b/packages/react-native/scripts/cocoapods/__tests__/utils-test.rb
index 44e0e3bcaa9c..c18eabe6eadf 100644
--- a/packages/react-native/scripts/cocoapods/__tests__/utils-test.rb
+++ b/packages/react-native/scripts/cocoapods/__tests__/utils-test.rb
@@ -1155,6 +1155,56 @@ def test_add_ndebug_flag_to_pods_in_release
         assert_equal("$(inherited) -DNDEBUG", custom_release_config2.build_settings["OTHER_CPLUSPLUSFLAGS"])
         assert_equal("$(inherited) -DNDEBUG", custom_release_config3.build_settings["OTHER_CPLUSPLUSFLAGS"])
     end
+
+    # ================================ #
+    # Test - ccache launcher env       #
+    # ================================ #
+
+    def test_ccacheLauncherEnv_exportsResolvedPaths
+        # Act
+        env = ReactNativePodsUtils.ccache_launcher_env("/opt/homebrew/bin/ccache", "/app/rn/scripts/xcode/ccache.conf")
+
+        # Assert
+        assert(env.include?("REACT_NATIVE_CCACHE_BINARY=/opt/homebrew/bin/ccache\n"))
+        assert(env.include?("REACT_NATIVE_CCACHE_CONFIGPATH=/app/rn/scripts/xcode/ccache.conf\n"))
+    end
+
+    def test_ccacheLauncherEnv_escapesPathsWithSpaces
+        # Act
+        env = ReactNativePodsUtils.ccache_launcher_env("/opt/homebrew/bin/ccache", "/Users/me/My App/rn/ccache.conf")
+
+        # Assert
+        assert(env.include?("REACT_NATIVE_CCACHE_CONFIGPATH=/Users/me/My\\ App/rn/ccache.conf\n"))
+    end
+
+    # ================================ #
+    # Test - remove ccache launcher    #
+    # ================================ #
+
+    def test_removeCcacheLauncher_removesCurrentLauncher
+        # Act
+        value = ReactNativePodsUtils.remove_ccache_launcher("$(PODS_ROOT)/ccache-clang.sh", "ccache-clang.sh")
+
+        # Assert
+        assert_equal("", value)
+    end
+
+    def test_removeCcacheLauncher_removesLauncherFromOlderReactNative
+        # Act
+        value = ReactNativePodsUtils.remove_ccache_launcher("$(REACT_NATIVE_PATH)/scripts/xcode/ccache-clang++.sh", "ccache-clang++.sh")
+
+        # Assert
+        assert_equal("", value)
+    end
+
+    def test_removeCcacheLauncher_keepsOtherCompilers
+        # Act
+        value = ReactNativePodsUtils.remove_ccache_launcher("/usr/bin/clang", "ccache-clang.sh")
+
+        # Assert
+        assert_equal("/usr/bin/clang", value)
+    end
+
 end
 
 # ===== #
diff --git a/packages/react-native/scripts/xcode/ccache-clang++.sh b/packages/react-native/scripts/cocoapods/ccache-clang++.sh
similarity index 55%
rename from packages/react-native/scripts/xcode/ccache-clang++.sh
rename to packages/react-native/scripts/cocoapods/ccache-clang++.sh
index 54ff8ba5816d..9bcae5c5e58e 100755
--- a/packages/react-native/scripts/xcode/ccache-clang++.sh
+++ b/packages/react-native/scripts/cocoapods/ccache-clang++.sh
@@ -4,11 +4,12 @@
 # This source code is licensed under the MIT license found in the
 # LICENSE file in the root directory of this source tree.
 
-# Get the absolute path of this script
-SCRIPT_DIR="$(dirname "$(readlink -f "$0")")"
+# Xcode gives a compiler launcher none of the build settings, so `pod install`
+# copies this script next to a generated environment file and points CC/LD at
+# the copy.
+. "$(dirname "$0")/ccache-launcher.env"
 
-REACT_NATIVE_CCACHE_CONFIGPATH=$SCRIPT_DIR/ccache.conf
 # Provide our config file if none is already provided
 export CCACHE_CONFIGPATH="${CCACHE_CONFIGPATH:-$REACT_NATIVE_CCACHE_CONFIGPATH}"
 
-exec $CCACHE_BINARY clang++ "$@"
+exec "$REACT_NATIVE_CCACHE_BINARY" clang++ "$@"
diff --git a/packages/react-native/scripts/xcode/ccache-clang.sh b/packages/react-native/scripts/cocoapods/ccache-clang.sh
similarity index 56%
rename from packages/react-native/scripts/xcode/ccache-clang.sh
rename to packages/react-native/scripts/cocoapods/ccache-clang.sh
index 9b1a355c2cce..6a732d91fd39 100755
--- a/packages/react-native/scripts/xcode/ccache-clang.sh
+++ b/packages/react-native/scripts/cocoapods/ccache-clang.sh
@@ -4,11 +4,12 @@
 # This source code is licensed under the MIT license found in the
 # LICENSE file in the root directory of this source tree.
 
-# Get the absolute path of this script
-SCRIPT_DIR="$(dirname "$(readlink -f "$0")")"
+# Xcode gives a compiler launcher none of the build settings, so `pod install`
+# copies this script next to a generated environment file and points CC/LD at
+# the copy.
+. "$(dirname "$0")/ccache-launcher.env"
 
-REACT_NATIVE_CCACHE_CONFIGPATH=$SCRIPT_DIR/ccache.conf
 # Provide our config file if none is already provided
 export CCACHE_CONFIGPATH="${CCACHE_CONFIGPATH:-$REACT_NATIVE_CCACHE_CONFIGPATH}"
 
-exec $CCACHE_BINARY clang "$@"
+exec "$REACT_NATIVE_CCACHE_BINARY" clang "$@"
diff --git a/packages/react-native/scripts/cocoapods/utils.rb b/packages/react-native/scripts/cocoapods/utils.rb
index f65d0798fcb5..b6e796be9b78 100644
--- a/packages/react-native/scripts/cocoapods/utils.rb
+++ b/packages/react-native/scripts/cocoapods/utils.rb
@@ -4,6 +4,7 @@
 # LICENSE file in the root directory of this source tree.
 
 require 'shellwords'
+require 'fileutils'
 require 'digest'
 require 'uri'
 require 'net/http'
@@ -156,6 +157,43 @@ def self.set_build_setting(installer, build_setting:, value:, config_name: nil)
         end
     end
 
+    # Values that only `pod install` can resolve, written next to the launcher
+    # scripts so that they can read them at build time.
+    def self.ccache_launcher_env(ccache_path, config_path)
+        <<~ENVFILE
+            # Generated by pod install. Edit scripts/cocoapods/utils.rb, not this file.
+            REACT_NATIVE_CCACHE_BINARY=#{Shellwords.escape(ccache_path)}
+            REACT_NATIVE_CCACHE_CONFIGPATH=#{Shellwords.escape(config_path)}
+        ENVFILE
+    end
+
+    # Older React Native versions pointed the build settings at the copy of the
+    # launcher shipped in node_modules, so both paths have to be recognized.
+    def self.remove_ccache_launcher(value, launcher_name)
+        [
+            File.join("$(PODS_ROOT)", launcher_name),
+            File.join("$(REACT_NATIVE_PATH)", 'scripts', 'xcode', launcher_name)
+        ].reduce(value) { |result, path| result.gsub(path, '') }
+    end
+
+    def self.generate_ccache_launchers(installer, react_native_path, ccache_path)
+        pods_root = installer.sandbox.root.to_s
+        config_path = File.expand_path(
+            File.join(react_native_path, 'scripts', 'xcode', 'ccache.conf'),
+            Pod::Config.instance.installation_root.to_s
+        )
+        File.write(
+            File.join(pods_root, 'ccache-launcher.env'),
+            self.ccache_launcher_env(ccache_path, config_path)
+        )
+
+        ['ccache-clang.sh', 'ccache-clang++.sh'].each do |name|
+            destination = File.join(pods_root, name)
+            FileUtils.cp(File.join(__dir__, name), destination)
+            File.chmod(0755, destination)
+        end
+    end
+
     def self.set_ccache_compiler_and_linker_build_settings(installer, react_native_path, ccache_enabled)
         projects = self.extract_projects(installer)
 
@@ -169,8 +207,8 @@ def self.set_ccache_compiler_and_linker_build_settings(installer, react_native_p
         end
 
         # Using scripts wrapping the ccache executable, to allow injection of configurations
-        ccache_clang_sh = File.join("$(REACT_NATIVE_PATH)", 'scripts', 'xcode', 'ccache-clang.sh')
-        ccache_clangpp_sh = File.join("$(REACT_NATIVE_PATH)", 'scripts', 'xcode', 'ccache-clang++.sh')
+        ccache_clang_sh = File.join("$(PODS_ROOT)", 'ccache-clang.sh')
+        ccache_clangpp_sh = File.join("$(PODS_ROOT)", 'ccache-clang++.sh')
 
         if ccache_available and ccache_enabled
             Pod::UI.puts("#{message_prefix}: Setting CC, LD, CXX & LDPLUSPLUS build settings")
@@ -182,25 +220,30 @@ def self.set_ccache_compiler_and_linker_build_settings(installer, react_native_p
                     config.build_settings["LD"] = ccache_clang_sh
                     config.build_settings["CXX"] = ccache_clangpp_sh
                     config.build_settings["LDPLUSPLUS"] = ccache_clangpp_sh
-                    config.build_settings["CCACHE_BINARY"] = ccache_path
                 end
 
                 project.save()
             end
-        elsif ccache_available and !ccache_enabled
-            Pod::UI.puts("#{message_prefix}: Pass ':ccache_enabled => true' to 'react_native_post_install' in your Podfile or set environment variable 'USE_CCACHE=1' to increase the speed of subsequent builds")
-        elsif !ccache_available and ccache_enabled
-            Pod::UI.warn("#{message_prefix}: Install ccache or ensure your neither passing ':ccache_enabled => true' nor setting environment variable 'USE_CCACHE=1'")
+
+            self.generate_ccache_launchers(installer, react_native_path, ccache_path)
         else
-            Pod::UI.puts("#{message_prefix}: Removing Ccache from CC, LD, CXX & LDPLUSPLUS build settings")
+            if ccache_available and !ccache_enabled
+                Pod::UI.puts("#{message_prefix}: Pass ':ccache_enabled => true' to 'react_native_post_install' in your Podfile or set environment variable 'USE_CCACHE=1' to increase the speed of subsequent builds")
+            elsif !ccache_available and ccache_enabled
+                Pod::UI.warn("#{message_prefix}: Install ccache or ensure your neither passing ':ccache_enabled => true' nor setting environment variable 'USE_CCACHE=1'")
+            else
+                Pod::UI.puts("#{message_prefix}: Removing Ccache from CC, LD, CXX & LDPLUSPLUS build settings")
+            end
 
+            # The launchers only exist when this install created them, so the
+            # settings cannot be left behind in any of these cases.
             projects.each do |project|
                 project.build_configurations.each do |config|
                     # Using the un-qualified names means you can swap in different implementations, for example ccache
-                    config.build_settings["CC"] = config.build_settings["CC"].gsub(/#{Regexp.escape(ccache_clang_sh)}/, '') if config.build_settings["CC"]
-                    config.build_settings["LD"] = config.build_settings["LD"].gsub(/#{Regexp.escape(ccache_clang_sh)}/, "") if config.build_settings["LD"]
-                    config.build_settings["CXX"] = config.build_settings["CXX"].gsub(/#{Regexp.escape(ccache_clangpp_sh)}/, "") if config.build_settings["CXX"]
-                    config.build_settings["LDPLUSPLUS"] = config.build_settings["LDPLUSPLUS"].gsub(/#{Regexp.escape(ccache_clangpp_sh)}/, "") if config.build_settings["LDPLUSPLUS"]
+                    config.build_settings["CC"] = self.remove_ccache_launcher(config.build_settings["CC"], 'ccache-clang.sh') if config.build_settings["CC"]
+                    config.build_settings["LD"] = self.remove_ccache_launcher(config.build_settings["LD"], 'ccache-clang.sh') if config.build_settings["LD"]
+                    config.build_settings["CXX"] = self.remove_ccache_launcher(config.build_settings["CXX"], 'ccache-clang++.sh') if config.build_settings["CXX"]
+                    config.build_settings["LDPLUSPLUS"] = self.remove_ccache_launcher(config.build_settings["LDPLUSPLUS"], 'ccache-clang++.sh') if config.build_settings["LDPLUSPLUS"]
                 end
 
                 project.save()